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Abstract #1877

Comparison of algorithms to determine Ventilated Volume Fraction from Oxygen-Enhanced MRI in Cystic Fibrosis

Marta Tibiletti1, Josephine H Naish1,2, Katharina Martini3, Thomas Frauenfelder 3, and Geoff JM Parker1,4

1Bioxydyn Limited, Manchester, United Kingdom, 2Division of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom, 3Institute for Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland, 4Quantitative biomedical Imaging Lab, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester, United Kingdom

We have compared four different algorithms to determine the ventilated volume fraction (VVF) in a population of 4 healthy volunteers and 21 cystic fibrosis adult patients who underwent volumetric dynamic oxygen-enhanced MRI at 1.5T. Results were compared with pulmonary function tests and a CT-based scoring system (Brody score). All considered methods present significant correlation between VVF and FEV1 (R2>0.5), FVC (R2>0.4), FEV1/FVC (R2>0.4). Weaker correlation was found between VVF and the Brody score (R2 ~0.2).

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