Abstract #1877

Comparison of algorithms to determine Ventilated Volume Fraction from Oxygen-Enhanced MRI in Cystic Fibrosis

Marta Tibiletti¹, Josephine H Naish^1,2, Katharina Martini³, Thomas Frauenfelder ³, and Geoff JM Parker^1,4

¹Bioxydyn Limited, Manchester, United Kingdom, ²Division of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom, ³Institute for Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland, ⁴Quantitative biomedical Imaging Lab, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester, United Kingdom

We have compared four different algorithms to determine the ventilated volume fraction (VVF) in a population of 4 healthy volunteers and 21 cystic fibrosis adult patients who underwent volumetric dynamic oxygen-enhanced MRI at 1.5T. Results were compared with pulmonary function tests and a CT-based scoring system (Brody score). All considered methods present significant correlation between VVF and FEV1 (R²>0.5), FVC (R²>0.4), FEV1/FVC (R²>0.4). Weaker correlation was found between VVF and the Brody score (R² ~0.2).

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