Abstract #1885

Ventilation Defect Percent from Hyperpolarized Helium-3 MRI as a predictor of Asthma Exacerbation Severity

Katherine J Carey¹, David G Mummy^1,2, Wei Zha¹, Michael Evans³, Chase Hall⁴, Mark L Schiebler⁵, Ronald Sorkness⁶, James D Quirk⁷, Dimitriy Yablonskiy⁷, Jason C Woods⁸, Loren C Denlinger⁹, Nizar N Jarjour⁹, Mario Castro¹⁰, and Sean B Fain^1,2,5

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ³Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, United States, ⁴Pulmonary and Critical Care Medicine, University of Kansas Medical Center, Kansas City, KS, United States, ⁵Radiology, University of Wisconsin-Madison, Madison, WI, United States, ⁶Pharmacy, University of Wisconsin-Madison, Madison, WI, United States, ⁷Radiology, Washington University St. Louis, St. Louis, MO, United States, ⁸Center for Pulmonary Imaging Research, University of Cincinnati Children's Hospital, Cincinnati, OH, United States, ⁹Allergy, Pulmonary, & Critical Care Medicine, University of Wisconsin-Madison, Madison, WI, United States, ¹⁰Pulmonary and Critical Care Medicine, Washington University St. Louis, St. Louis, MO, United States

We assessed ventilation defect percent (VDP) on hyperpolarized (HP) ³He MRI in 28 asthmatics at baseline and recovery visits following an exacerbation (10 ± 7 months apart). We found that pre-bronchodilator VDP at baseline was a stronger predictor of severe exacerbations than conventional asthma control indices, and subjects that underwent a severe exacerbation had highly variable VDP changes after recovery. These findings suggest that VDP is a potential biomarker of asthma instability.

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