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Abstract #1896

Feasibility of 3D PREFUL: 3D dynamic lung ventilation imaging, initial comparison to 2D PREFUL in healthy volunteers

Filip KlimeŇ°1,2, Andreas Voskrebenzev1,2, Marcel Gutberlet1,2, Grzegorz Bauman3,4, Oliver Bieri3,4, Robert Grimm5, Tawfik Moher Alsady1,2, Frank Wacker1,2, and Jens Vogel-Claussen1,2

1Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Centre for Lung Research (DZL), Hannover, Germany, 3Department of Radiology, University of Basel Hospital, Basel, Switzerland, 4Department of Biomedical Engineerings, University of Basel, Basel, Switzerland, 5Siemens Healthcare GmbH, Erlangen, Germany

Pulmonary ventilation assessed by Fourier Decomposition (FD) is limited by its 2D acquisition and does not consider dynamics of ventilation. In this work, a method to assess dynamic lung ventilation in 3D using self-gating and phase-resolved functional lung imaging (PREFUL) is presented. The full respiratory cycle was reconstructed and dynamic regional ventilation (RV) maps were generated. Mean slice correlation and anterior-posterior gradient of ventilation values were compared between the 3D and the 2D PREFUL approaches. 3D PREFUL imaging was able to reconstruct dynamic imaging of the respiratory cycle, generate dynamic RV maps and provide good agreement with the 2D approach.

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