Abstract #1896

Feasibility of 3D PREFUL: 3D dynamic lung ventilation imaging, initial comparison to 2D PREFUL in healthy volunteers

Filip Klimeš^1,2, Andreas Voskrebenzev^1,2, Marcel Gutberlet^1,2, Grzegorz Bauman^3,4, Oliver Bieri^3,4, Robert Grimm⁵, Tawfik Moher Alsady^1,2, Frank Wacker^1,2, and Jens Vogel-Claussen^1,2

¹Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Centre for Lung Research (DZL), Hannover, Germany, ³Department of Radiology, University of Basel Hospital, Basel, Switzerland, ⁴Department of Biomedical Engineerings, University of Basel, Basel, Switzerland, ⁵Siemens Healthcare GmbH, Erlangen, Germany

Pulmonary ventilation assessed by Fourier Decomposition (FD) is limited by its 2D acquisition and does not consider dynamics of ventilation. In this work, a method to assess dynamic lung ventilation in 3D using self-gating and phase-resolved functional lung imaging (PREFUL) is presented. The full respiratory cycle was reconstructed and dynamic regional ventilation (RV) maps were generated. Mean slice correlation and anterior-posterior gradient of ventilation values were compared between the 3D and the 2D PREFUL approaches. 3D PREFUL imaging was able to reconstruct dynamic imaging of the respiratory cycle, generate dynamic RV maps and provide good agreement with the 2D approach.

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