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Abstract #1905

The Effects of Fixation and Age on Relaxometry Measurements of Ex-Vivo Kidneys

Alexander J Daniel1, Charlotte E Buchanan1, Isma Kazmi2, Eleanor F Cox1, Nicholas M Selby2, David S Gardner3, and Susan T Francis1

1Sir Peter Mansfield Imaging Centre, The University of Nottingham, Nottingham, United Kingdom, 2Centre for Kidney Research and Innovation, The University of Nottingham, Nottingham, United Kingdom, 3School of Veterinary Medicine and Science, The University of Nottingham, Leicestershire, United Kingdom

The study of post-mortem brain tissue using MRI has been shown to provide a tool to assess whole organ microstructure and pathology with high spatial resolution. However, few studies have been performed on other organs in the body, here we perform ex-vivo imaging of whole kidneys. T1 and T2* of ex-vivo porcine kidneys are monitored over a ten-week period to study how T1 and T2* of the renal cortex and medulla vary over time from fixation. A clear understanding of the effects of fixation on tissue MRI parameters is crucial for interpreting ex-vivo MRI studies.

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