Abstract #1933

Skeletal Muscle Adipose Tissue Quantification in Diabetic Peripheral Neuropathy

Amanda Ho¹, Shannon Haas¹, Antonio Convit², Kenneth Mroczek³, Jill Slade⁴, Prodromos Parasoglou¹, and Ryan Brown^1,5,6

¹Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States, ²Department of Psychiatry, New York University School of Medicine, New York, NY, United States, ³Department of Orthopaedic Surgery, New York University Langone Hospital for Joint Diseases, New York, NY, United States, ⁴Department of Radiology, Michigan State University, East Lansing, MI, United States, ⁵Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, NY, United States, ⁶Sackler Institute of Graduate Biomedical Sciences, New York University School of Medicine, New York, NY, United States

Diabetic peripheral neuropathy (DPN) is a common and serious complication of diabetes, where persistent hyperglycemia impairs metabolic and microvascular function, ultimately resulting in fatty infiltration. Quantitative adipose measurements using MRI may provide a useful tool to evaluate the effects of therapeutic intervention. We tested a chemical-shift based technique to measure skeletal muscle fatty infiltration in a cohort with DPN. Fatty infiltration was found to be increased in the ankle plantar flexors of DPN patients, with significant elevation detected in the medial gastrocnemius muscle.

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