Non-alcoholic fatty liver disease (NAFLD) is a rapidly increasing health problem in world wide. NAFLD comprises a wide spectrum of liver damage, ranging from simple macrovesicular steatosis, liver inflammation, fibrosis, and cirrhosis. Liver biopsy has been regarded as the reference standard for diagnosing hepatic inflammation, fibrosis and cirrhosis in NAFLD. A subset non-alcoholic steatohepatitis (NASH) is the early stage of progression that develops to cirrhosis in 15-25% of patients and can lead to the development of hepatocellular carcinoma. Thus, non-invasive diagnostics of NASH are clinically important issue and are warranted. Recently, considerable effort is underway to identify screening strategies that non-invasively diagnose NASH using a variety of techniques such as laboratory tests and imaging techniques. Up to date, there are several published studies using serum biochemical tests, ultrasound and CT, however there was no strong evidence in clinical practice. In this study, the diagnostic accuracy in NAFLD using 1H MR modality have not yet been clearly identified. Our meta-analysis study was estimated the accuracy of 1H MRI on this topic, non-invasively diagnosing NASH.
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