Abstract #1985

Non-Invasive Evaluation of Inhaled Nitric Oxide on Pulmonary Blood Flow Dynamics using 4D Flow MRI in Pediatric Pulmonary Arterial Hypertension Patients

Nivedita K Naresh¹, Michal Schafer², Lorna Browne¹, Dunbar Ivy², Dayna Zimmerman³, Vitaly Kheyfets⁴, Alexander J. Barker^1,4, and Uyen Truong²

¹Radiology, Children's Hospital Colorado, Aurora, CO, United States, ²Cardiology, Children's Hospital Colorado, Aurora, CO, United States, ³Pediatrics, Children's Hospital Colorado, Aurora, CO, United States, ⁴Bioengineering, University of Colorado Denver, Aurora, CO, United States

Pediatric pulmonary arterial hypertension (PAH) is a significant cause of morbidity and mortality. Acute vasodilatory reactivity (AVR) using right heart catheterization is a necessary component of a diagnostic PAH evaluation. The aim of this study was to non-invasively evaluate AVR hemodynamic changes in pediatric patients with PAH using 4D flow MRI. We have shown that post-iNO treatment in pediatric PAH patients, peak velocity and peak wall shear stress were increased. Future studies in larger cohorts of PAH pediatric patients are needed to comprehensively evaluate the effectiveness of non-invasive AVR in comparison to gold standard right heart catheterization.

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