Abstract #1991

Non-invasive estimations of turbulence driven relative pressure drops – applying the concept of virtual fields on 4D flow MRI

David Marlevi^1,2, Hojin Ha^3,4, Joao Filipe Fernandes⁵, Tino Ebbers⁴, Pablo Lamata⁵, and David Nordsletten^5,6

¹Department of Biomedical Engineering and Health Systems, KTH Royal Institute of Technology, Stockholm, Sweden, ²Clinical Sciences, Karolinska Institutet, Stockholm, Sweden, ³Department of Mechanical and Biomedical Engineering, Kangwon National University, Chuncheon, Korea, Republic of, ⁴Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, ⁵Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, ⁶Departments Biomedical Engineering and Cardiac Surgery, University of Michigan, Ann Arbor, MI, United States

4D flow MRI with six-directional flow encoding has enabled the assessment of turbulent flows, including mapping of incoherent flow variance. Using such, non-invasive estimation of turbulence-driven pressure drops can be computed. Here, we present an extension of the virtual-Work-Energy-Relative-Pressure method⁸ for the assessment of turbulence-driven pressure drops. Using the concept of virtual fields, the method accurately assesses pressure drops over a range of stenotic valve phantoms, being validated against catheter-based measurements. With virtual probing enabling the assessment of pressure drops through complex, narrow vasculatures, the incorporation of turbulence enhances the utility of the method, enabling for refined clinical hemodynamic analysis.

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