Abstract #2006

Impact of a ten-year national Italian networking on cardiac complications in patients with thalassemia major

Antonella Meloni¹, Laura Pistoia¹, Riccardo Righi², Nicolò Schicchi³, Stefania Renne⁴, Antonino Vallone⁵, Emanuele Grassedonio⁶, Gennaro Restaino⁷, Saveria Campisi⁸, Sabrina Armari⁹, Vincenzo Positano¹, and Alessia Pepe¹

¹Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy, ²Ospedale del Delta, Lagosanto (FE), Italy, ³Azienda Ospedaliero-Universitaria Ospedali Riuniti "Umberto I-Lancisi-Salesi", Ancona, Italy, ⁴Presidio Ospedaliero “Giovanni Paolo II”, Lamezia Terme (CZ), Italy, ⁵Azienda Ospedaliera "Garibaldi", Presidio Ospedaliero Nesima, Catania, Italy, ⁶Policlinico "Paolo Giaccone", Palermo, Italy, ⁷Fondazione di Ricerca e Cura "Giovanni Paolo II", Campobasso, Italy, ⁸Presidio Ospedaliero “Umberto I”, Siracusa, Italy, ⁹Azienda Ospedaliera di Legnago, Legnago (VR), Italy

Over a period of 10 years, the continuous monitoring of cardiac iron levels and a tailored chelation therapy allowed a reduction of myocardial iron overload (MIO) in the 70% of patients with thalassemia major (TM) enrolled in the MIOT (Myocardial Iron Overload in Thalassemia) Network. A consequent improvement of cardiac function and a reduction of heart failure were detected. So, a national networking was effective in improving the care and reducing cardiac outcomes of TM patients.

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