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Abstract #2006

Impact of a ten-year national Italian networking on cardiac complications in patients with thalassemia major

Antonella Meloni1, Laura Pistoia1, Riccardo Righi2, Nicolò Schicchi3, Stefania Renne4, Antonino Vallone5, Emanuele Grassedonio6, Gennaro Restaino7, Saveria Campisi8, Sabrina Armari9, Vincenzo Positano1, and Alessia Pepe1

1Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy, 2Ospedale del Delta, Lagosanto (FE), Italy, 3Azienda Ospedaliero-Universitaria Ospedali Riuniti "Umberto I-Lancisi-Salesi", Ancona, Italy, 4Presidio Ospedaliero “Giovanni Paolo II”, Lamezia Terme (CZ), Italy, 5Azienda Ospedaliera "Garibaldi", Presidio Ospedaliero Nesima, Catania, Italy, 6Policlinico "Paolo Giaccone", Palermo, Italy, 7Fondazione di Ricerca e Cura "Giovanni Paolo II", Campobasso, Italy, 8Presidio Ospedaliero “Umberto I”, Siracusa, Italy, 9Azienda Ospedaliera di Legnago, Legnago (VR), Italy

Over a period of 10 years, the continuous monitoring of cardiac iron levels and a tailored chelation therapy allowed a reduction of myocardial iron overload (MIO) in the 70% of patients with thalassemia major (TM) enrolled in the MIOT (Myocardial Iron Overload in Thalassemia) Network. A consequent improvement of cardiac function and a reduction of heart failure were detected. So, a national networking was effective in improving the care and reducing cardiac outcomes of TM patients.

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