Abstract #2027

Intramyocardial and Pericardial Fat Quantification in Boys with Duchenne Muscular Dystrophy and Healthy Controls at 3T.

Nyasha G Maforo^1,2, Holden H Wu¹, Patrick Magrath³, Pierangelo Renella⁴, Nancy Halnon⁵, and Daniel B Ennis^6,7

¹Radiology, University of California, Los Angeles, Los Angeles, CA, United States, ²Physics and Biology in Medicine IDP, University of California, Los Angeles, Los Angeles, CA, United States, ³Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ⁴Radioloy, University of California, Los Angeles, Los Angeles, CA, United States, ⁵Pediatrics, University of California, Los Angeles, Los Angeles, CA, United States, ⁶Radiological Sciences Lab, Stanford, Stanford, CA, United States, ⁷Radiology, Stanford, Stanford, CA, United States

Emerging cardiac MRI biomarkers of Duchenne muscular dystrophy (DMD), a fatal X-linked genetic disorder, include intra-myocardial fibro-fatty infiltration, to identify the onset of microstructural remodeling in boys with DMD. The study aims were to: 1) characterize and compare intra-myocardial signal fat fraction (sFF) between boys with DMD and healthy controls; and 2) report and compare pericardial fat volume and sFF estimates in boys with DMD and healthy controls. We detected no intra-myocardial and pericardial sFF differences between DMD boys and healthy controls respectively. Boys with DMD presented with significantly more pericardial fat volume compared to healthy boys.

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