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Abstract #2032

A real-time myocardial velocity encoding sequence to optimize trigger delay in motion-compensated cardiac DWI

Anne-Lise Le Bars1, Kévin Moulin2, Daniel B. Ennis2, Jesús E. Dos Reis1, Laurent Bonnemains1,3,4, Jacques Felblinger1,5, Chen Bailiang1,5, and Odille Freddy1,5

1IADI, INSERM U1254 and Université de Lorraine, Nancy, France, 2Department of Radiology, Stanford University, Stanford, CA, United States, 3Department of Cardiothoracic Surgery, CHU Strasbourg, Strasbourg, France, 4Université de Strasbourg, Strasbourg, France, 5CIC-IT, INSERM 1433, Université de Lorraine and CHRU Nancy, Nancy, France

Motion-compensated spin echo sequences have been developed to obtain diffusion sensitivity in the presence of bulk cardiac motion. First and second order motion can be compensated but higher order motion can occur in certain cardiac phases. Here, we propose a real-time velocity-encoded sequence (6ms time resolution) to optimize and adapt the trigger delay on a subject-specific basis. In one volunteer, the variability in diffusion signal was analyzed as a function of trigger delay and compared to myocardial velocity profiles. Mid-systole was found to provide the most reliable ADC and conversely the worst ADC was found in early diastole.

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