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Abstract #2046

Ex-vivo Diffusion Tensor Imaging of the Porcine Heart at Ultra High Field Strength - 7T: Impacts of Tissue Fixation Duration and Stimulated Echo Mixing Time

David Lohr1, Maxim Terekhov1, Sebastian Kress2, Franziska Veit2, Heike Walles3, and Laura Maria Schreiber1

1Chair of Cellular and Molecular Imaging, Comprehensive Heart Failure Center (CHFC), University Hospital Wuerzburg, Wuerzburg, Germany, 2Chair of Tissue Engineering and Regenerative Medicine (TERM), University Hospital Wuerzburg, Wuerzburg, Germany, 3Translational Center Regenerative Therapies (TLC-RT), Fraunhofer Institute for Silicate Research (ISC), Wuerzburg, Germany

Diffusion time dependent changes of ADC, FA, HA were analyzed in two fixed, excised porcine hearts using a stimulated echo approach at 7T with mixing times 50-1000ms. A standard SE-method was used as a reference and SNR differences were evaluated using the multiple image method. The data will allow better comparison of in-vivo measurements using SE- and STE-approaches. Ex-vivo measurements, which can provide high fidelity data at resolutions unachievable in-vivo, are usually performed on fixed tissue. We therefore assessed the impact of tissue fixation on T2 and T2* at 7T, which will allow optimization of future acquisition protocols.

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