Abstract #2046

Ex-vivo Diffusion Tensor Imaging of the Porcine Heart at Ultra High Field Strength - 7T: Impacts of Tissue Fixation Duration and Stimulated Echo Mixing Time

David Lohr¹, Maxim Terekhov¹, Sebastian Kress², Franziska Veit², Heike Walles³, and Laura Maria Schreiber¹

¹Chair of Cellular and Molecular Imaging, Comprehensive Heart Failure Center (CHFC), University Hospital Wuerzburg, Wuerzburg, Germany, ²Chair of Tissue Engineering and Regenerative Medicine (TERM), University Hospital Wuerzburg, Wuerzburg, Germany, ³Translational Center Regenerative Therapies (TLC-RT), Fraunhofer Institute for Silicate Research (ISC), Wuerzburg, Germany

Diffusion time dependent changes of ADC, FA, HA were analyzed in two fixed, excised porcine hearts using a stimulated echo approach at 7T with mixing times 50-1000ms. A standard SE-method was used as a reference and SNR differences were evaluated using the multiple image method. The data will allow better comparison of in-vivo measurements using SE- and STE-approaches. Ex-vivo measurements, which can provide high fidelity data at resolutions unachievable in-vivo, are usually performed on fixed tissue. We therefore assessed the impact of tissue fixation on T₂ and T₂^* at 7T, which will allow optimization of future acquisition protocols.

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