Abstract #2054

Comparison of Gadolinium- and Ferumoxytol- enhanced Conventional and ultra-short echo time MR-Angiography for the Depiction of the Pulmonary Vasculature

Gesine Knobloch¹, Timothy Colgan¹, Mark Schiebler¹, Kevin M. Johnson^1,2, Tilman Schubert¹, Scott B. Reeder^1,2,3,4,5, and Scott Nagle ^1,2,6

¹Radiology, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States, ²Medical Physics, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States, ³Biomedical Engineering, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States, ⁴Medicine, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States, ⁵Emergency Medicine, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States, ⁶Pediatrics, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States

Pulmonary MRA is a promising technique for detection of pulmonary embolism without ionizing radiation. Unfortunately, a subset of patients fail breath-holding during conventional MRA (cMRA). Free-breathing ultra-short echo time (UTE)-MRA could overcome this limitation but would require a blood pool contrast agent due to longer scan times. Ferumoxytol (FE) can be used as an off-label MR-contrast agent with a blood half-life of 10-14 hours. This study compared gadobenate dimeglumine (GD)-enhanced-UTE-MRA to FE-cMRA and FE-UTE-MRA, using GD-cMRA as reference standard. Results suggest that FE-UTE-MRA has improved performance compared to GD-cMRA for depicting non-vascular structures while offering excellent angiographic image quality.

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