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Abstract #2080

Plaque permeability assessed with dynamic contrast-enhanced MRI predicts ferumoxytol nanoparticle delivery in patients with peripheral artery disease

Kang H. Zheng1, Jasper Schoormans2, Lotte Stiekema1, Claudia Calcagno3, Iwona Cicha4, Aart J Nederveen5, Gustav J Strijkers2, Erik S.G. Stroes1, and Bram F Coolen2

1Department of Vascular Medicine, Amsterdam UMC, Amsterdam, Netherlands, 2Department of Biomedical Engineering and Physics, Amsterdam UMC, Amsterdam, Netherlands, 3TMII, Icahn School of Medicine, New York, NY, United States, 4University Hospital Erlangen, Erlangen, Germany, 5Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands

We investigated whether dynamic-contrast enhanced (DCE-)MRI could be used to predict accumulation of ferumoxytol nanoparticles in femoral plaques. To this end, we implemented USPIO enhanced quantitative T2* imaging, as well as 3D black-blood DCE-MRI sequences for femoral artery vessel wall imaging. Patients with peripheral artery disease (PAD) and healthy volunteers were included in this study. We show that ferumoxytol nanoparticle delivery to atherosclerotic plaques is associated with plaque permeability as assessed with DCE-MRI in patients with PAD.

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