Abstract #2095

CrCEST reveals characteristics of skeletal muscle creatine metabolism in patients with Peripheral Arterial Disease

Helen Sporkin¹, Roshin Mathew², Christopher Kramer^2,3, and Craig Meyer^1,3

¹Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, ²Cardiovascular Imaging, University of Virginia, Charlottesville, VA, United States, ³Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States

Peripheral arterial disease (PAD) is an atherosclerotic disease of the limbs. Creatine chemical exchange saturation transfer (CrCEST) MRI can be used to visualize creatine metabolism as it occurs in the muscles of the calf. We have successfully applied CrCEST in 13 healthy subjects and 7 PAD patients in order to characterize the effect of ischemia on skeletal muscle energetics. Creatine concentration decay was assessed by CrCEST over a period of 8 minutes after plantarflexion exercise. Time course CEST asymmetry plots show features of PAD decays that help reveal mechanisms of metabolic dysfunction.

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