Abstract #2102

3D cardiac MR elastography can monitor therapy for heart failure with preserved ejection fraction: feasibility in a porcine model

Shivaram Poigai Arunachalam¹, Arvin Arani¹, Dawn M Pedrotty², Alan M Sugrue², Suganti Shivaram¹, Phillip J Rossman¹, Joshua D Trzasko¹, Kevin J Glaser¹, Yi Sui¹, Armando Manduca³, Kiaran P McGee¹, Richard L Ehman¹, Barry A Borlaug², and Philip A Araoz¹

¹Radiology, Mayo Clinic, Rochester, MN, United States, ²Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States, ³Biomedical Engineering and Physiology, Mayo Clinic, Rochester, MN, United States

Heart failure with preserved ejection fraction (HFpEF) is an increasingly common clinical syndrome with diagnostic challenges and no effective treatment which is characterized by increased cardiac filling pressures resulting in increased myocardial stiffness. The purpose of this study was to assess changes in myocardial stiffness after pericardiectomy in a pig model of HFpEF, and to demonstrate the feasibility of Cardiac MR Elastography (CMRE) as a noninvasive tool to monitor treatment in HFpEF. Results show a significant decrease in myocardial stiffness aster pericardiectomy implying the potential of CMRE for treatment design, planning and monitoring for HFpEF in humans

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