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Abstract #2104

Estimating Aggregate Cardiomyocyte Shortening Using Diffusion and Displacement Encoded MRI

Ilya Alexey Verzhbinsky1, Luigi Emanuele Perotti2, Kévin Moulin1, Michael Loecher1, and Daniel B Ennis1

1Radiological Sciences Laboratory, Stanford University, Stanford, CA, United States, 2Radiological Sciences, University of California - Los Angeles, Los Angeles, CA, United States

Orientation and deformation changes of left ventricular cardiomyocyte aggregates (“myofibers”) underlie many forms of cardiovascular disease. In vivo cardiomyocyte aggregate shortening (Eff) has mechanistic significance, but there exists no established technique to measure in vivo Eff. We present a pipeline to compute Eff by combining multi-slice Displacement Encoded with Stimulated Echoes (DENSE) MRI and in vivo cardiac Diffusion Tensor Imaging (cDTI) data. We show that Eff computed in healthy swine has decreased transmural variability compared to radial and circumferential strains. The spatial uniformity and mechanistic significance of Eff make it a compelling candidate for early detection of cardiac dysfunction.

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