The prevalence and prognoses of cardiac diseases differ between men and women due to a number of physiological factors. However, the implications of these differences on cardiac flow dynamics are not yet fully understood. In this study, healthy volunteers were imaged with four-dimensional flow and bSSFP MRI. Differences were observed between metrics of ventricular kinetic energy, ventricular flow vorticity, myocardial strain, and efficiency indices. Results may, in part, explain the hypothesized physiological protective effects of the pre-menopausal female heart, and their relevance to efficient cardiac flow dynamics.