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Abstract #2150

Doxorubicin induced cardiotoxicity highlighted from the combination of CMR, exercise tests data and CircAdapt model.

Tanguy Artz1, Daniel Curnier2, and Delphine Perie1

1Polytechnique Montreal, Montreal, QC, Canada, 2Université de Montréal, Montreal, QC, Canada

This study aims to discriminate three risk groups of leukemia survivors investigating subtle changes in their myocardium mechanical properties. Volumes extracted from cine-MRI images coupled to incremental exercise data allowed the quantification of the mechanical properties of the left ventricle using a reverse material identification approach based on the CircAdapt model. While both passive and active properties did not show significant changes in ALL survivors between risk groups, the increased arteriovenous pressure drop suggested that the cardioprotective agent entailed a compensation of the cardiac function through the peripheral components of the oxygen delivery chain.

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