Abstract #2164

Intra-Exam Repeatability of CINE DENSE Strain in Duchenne Muscular Dystrophy

Patrick Magrath^1,2, Nyasha Maforo^2,3, Mike Loecher ⁴, Holden H. Wu^1,2,3, Pierangelo Renella ², Nancy Halnon ⁵, and Daniel B. Ennis ⁶

¹Bioengineering, University of California, Los Angeles, CA, United States, ²Radiological Sciences, University of California, Los Angeles, CA, United States, ³Physics and Biology in Medicine, University of California, Los Angeles, CA, United States, ⁴Stanford University, Stanford, CA, United States, ⁵Pediatrics (Cardiology), University of California, Los Angeles, CA, United States, ⁶Radiology, Stanford University, Stanford, CA, United States

Heart failure leads the causes of mortality in Duchenne Muscular Dystrophy (DMD), the most common fatal genetic disorder. Circumferential strain (E_cc) is a promising biomarker for improved diagnosis and evaluation of therapy, but its repeatability has not been evaluated in a DMD cohort. The objective was to quantify the intra-exam repeatability of peak mid-wall circumferential (E_cc) strain derived from CINE DENSE in boys with DMD (N=11) compared to age-matched controls (N=10). Intra-scan repeatability was high, with a smallest detectable change in strain of 0.005, well under the previously reported 0.013±0.015 decrease in E_cc/year reported in boys with DMD.

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