Abstract #2177

Ex Vivo Cardiovascular Model Design and Construction: Preliminary Results

Timothy Ruesink¹, Ryan J Pewowaruk², Joshua L Hermsen³, Petros V Anagnostopoulos³, and Alejandro Roldán-Alzate^1,2,4

¹Mechanical Engineering, University of Wisconsin, Madison, WI, United States, ²Biomedical Engineering, University of Wisconsin, Madison, WI, United States, ³Department of Surgery, University of Wisconsin, Madsion, WI, United States, ⁴Radiology, University of Wisconsin, Madison, WI, United States

Cardiovascular fluid dynamics (CFD) has clinical application and is often studied in vitro, in vivo or using computational simulation. However, inherent assumptions and limitations of these methods limit their clinical translation. Ex vivo modeling, coupled with 4D Flow MRI, can provide physiological time-resolved velocity data, while overcoming limitations of other experimental methods. An ex vivo MRI model of a porcine aorta was designed and assessed for its use in cardiovascular modeling and pulse wave velocity (PWV) measurement validation. Physiologically reasonable flow, produced at the specimen inlet, and preliminary PWV data show potential for future CFD and validation studies.

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