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Abstract #2194

Dynamic T1 Mapping for Quantitative Myocardial Perfusion Imaging

Christoph Kolbitsch1,2, Kirsten Miriam Becker1, Judith Lehnert1, Jean Pierre Bassenge1,3, Xenios Milidonis2, Myles Capstick4, Amedeo Chiribiri2, and Tobias Schaeffter1,2

1Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany, 2School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, 3Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrueck Center for Molecular Medicine, Berlin, Germany, 4ZMT Zurich MedTech AG, Zurich, Switzerland

Myocardial perfusion imaging is a valuable diagnostic tool to assess cardiac viability. Quantitative perfusion imaging promises to provide absolute values of myocardial perfusion allowing for objective disease assessment and monitoring. Here we present a phantom study evaluating accuracy and reproducibility of a high-resolution dynamic T1 mapping approach to directly measure changes in contrast agent concentration and yield quantitative myocardial perfusion without the need of signal-intensity calibration. Our proposed technique provides one high-resolution T1 map for each cardiac cycle and leads to accurate myocardial perfusion values verified with standard 2D phase-contrast MRI (difference of estimated flow 10 – 20%).

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