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Abstract #2200

Impact of temporal resolution on the quantification of myocardial perfusion in dynamic-contrast enhanced MRI

Xenios Milidonis1, Muhummad Sohaib Nazir1, Russell Franks1, and Amedeo Chiribiri1

1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom

Quantification of myocardial perfusion using dynamic contrast enhanced imaging provides an objective and sensitive assessment of coronary artery disease in the clinic. While many factors were found to affect the accuracy of perfusion estimates, there has been little evidence on the impact of temporal resolution. This study sheds light on this using simulated, phantom and clinical data. Simulations and phantom experiments demonstrate large deviations between measurements when the same data are sampled with different temporal resolutions, while interpolation of clinical data to uniform temporal resolution leads to significantly different perfusion rates.

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