Quantification of myocardial perfusion using dynamic contrast enhanced imaging provides an objective and sensitive assessment of coronary artery disease in the clinic. While many factors were found to affect the accuracy of perfusion estimates, there has been little evidence on the impact of temporal resolution. This study sheds light on this using simulated, phantom and clinical data. Simulations and phantom experiments demonstrate large deviations between measurements when the same data are sampled with different temporal resolutions, while interpolation of clinical data to uniform temporal resolution leads to significantly different perfusion rates.
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