Abstract #2231

Optimal Analysis Strategies for GABA Quantification with 1H J-Edited MRS

Jeffry R. Alger^1,2,3, Joseph O'Neill⁴, Ronald Ly⁴, Guldamla Kalender⁴, Shantanu H. Joshi¹, Katherine L. Narr¹, Mary J. O'Connor⁴, and Jennifer G. Levitt⁴

¹Neurology, University of California, Los Angeles, Los Angeles, CA, United States, ²Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ³NeuroSpectroScopics LLC, Sherman Oaks, CA, United States, ⁴Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, United States

This study evaluated the performance of 9 unique methods of deriving GABA and GABA+ from J-edited-single-voxel-MRS using a set of high-quality spectra obtained from the anterior middle cingulate cortex in 34 pediatric human subjects. The results indicate that spectral integration produces the most consistent between-subject measure of GABA+ and that non-linear least-squares fitting that includes macromolecule confound spectral models together with GABA spectral models best produces the expected positive correlation between voxel gray matter content and GABA.

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