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Abstract #2231

Optimal Analysis Strategies for GABA Quantification with 1H J-Edited MRS

Jeffry R. Alger1,2,3, Joseph O'Neill4, Ronald Ly4, Guldamla Kalender4, Shantanu H. Joshi1, Katherine L. Narr1, Mary J. O'Connor4, and Jennifer G. Levitt4

1Neurology, University of California, Los Angeles, Los Angeles, CA, United States, 2Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 3NeuroSpectroScopics LLC, Sherman Oaks, CA, United States, 4Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, United States

This study evaluated the performance of 9 unique methods of deriving GABA and GABA+ from J-edited-single-voxel-MRS using a set of high-quality spectra obtained from the anterior middle cingulate cortex in 34 pediatric human subjects. The results indicate that spectral integration produces the most consistent between-subject measure of GABA+ and that non-linear least-squares fitting that includes macromolecule confound spectral models together with GABA spectral models best produces the expected positive correlation between voxel gray matter content and GABA.

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