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Abstract #2236

Macromolecule free measurement of GABA with MASE-sLASER and MEGA-sLASER sequences in the human brain at 7T

Seyedmorteza Rohani Rankouhi1, Donghyun Hong1, and David G. Norris1,2

1Erwin L. Hahn Institute for Magnetic Resonance Imaging, Essen, Germany, 2Donders Institute for Brain, Cognition and Behavior, Nijmegen, Netherlands

MEGA edited 3 ppm signal can be severely contaminated with macro-molecules. Using two distinct acquisition methods of MASE-sLASER and MEGA-sLASER both at TE = 68 ms at 7T, we show the feasibility of macromolecule free estimation of GABA with LCModel. The presence of GABA line at 2.28 ppm in the spectra acquired with both techniques plays a crucial role for this.

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