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Abstract #2272

Characterizing the relationships between early systemic cytokine levels and neurochemical changes in Alzheimer’s disease: A longitudinal neuroimaging study in the TgF344-AD rodent model

Katrina Cruickshank1,2, Tak Pan Wong2,3, and Jamie Near2,3

1Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada, 2Douglas Mental Health University Institute, Verdun, QC, Canada, 3Department of Psychiatry, McGill University, Montreal, QC, Canada

Cytokines are chemical signalling molecules released by the immune system in response to pathological insults. Cytokine upregulation is an early feature of Alzheimer’s disease (AD) and a possible contributor to downstream neuropathology and cognitive decline. Using magnetic resonance spectroscopy (MRS), cytokine-specific enzyme-linked immunosorbent assays (ELISA) and behavioural measures, we aimed to investigate the relationships between cytokine activity, early neurochemical changes and cognitive decline in an AD rodent model. Preliminary metabolic alterations suggest a paradoxical increase in synaptic activity, coinciding with cognitive deficits. This ongoing study is a step towards understanding the impact of abnormal cytokine levels on the AD brain.

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