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Abstract #2279

Brain regional susceptibility to Oxidative Stress in a rat model of Chronic Hepatic Encephalopathy: in-vivo 1H MRS, ex-vivo ESR spectroscopy and histology findings

Katarzyna Pierzchala1, Dunja Simicic1, Veronika Rackayova1, Olivier Braissant2, Dario Sessa3, Stefanita Mitrea1, Andrzej Sienkiewicz4, Valérie McLin5, Rolf Gruetter1, and Cristina Cudalbu1

1Center for Biomedical Imaging, EPFL, Lausanne, Switzerland, 2Service of Biomedicine, CHUV, Lausanne, Switzerland, 3Swiss Center for Liver Disease in Children, Department of Pediatrics, HUG, Lausanne, Switzerland, 4Laboratory of Physics of Complex Matter, EPFL, Lausanne, Switzerland, 5Swiss Center for Liver Disease in Children, Department of Pediatrics, HUG, Geneva, Switzerland

Oxidative stress (OS) is thought to be an important factor in chronic hepatic encephalopathy (CHE) pathogenesis. Combining in-vivo 1H-MRS, ex-vivo ESR and histology of CNS allowed us to investigate the course and brain regional difference of cerebral OS in the rat model of CHE. Early changes in brain antioxidants (Asc and GSH, post-BDL) were validated by ESR and histology. Our results showed a stronger vulnerability of cerebellum and confirmed that the antioxidant system impairment and central OS is an early event in CHE.

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