The present study demonstrates the potential of proton nuclear magnetic resonance (1H-NMR) based metabolic profiling of urine for distinguishing prostate cancer patients (PCa; n=43) from patients with benign prostatic hyperplasia (BPH; n=30) and to determine non-invasive biomarker/s for diagnosis. A significantly lower concentration of leucine, valine, hippurate, dimethylglycine, glycerophosphocholine, glutamine, glycine, taurine and creatinine were observed in PCa patients as compared to BPH. Our result suggests metabolic alterations due to protein turnover, cell proliferation, energy demand and gut micro-biota metabolism in PCa patients.
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