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Abstract #2291

Assessment of Thalamic Metabolic Processes in a Migraine Model: A Relaxation Enhanced Diffusion Weighted MRS Study at 21.1 T

Nastaren Abad1,2, Jens T Rosenberg2, Tangi Roussel3, Michael G Harrington4, and Samuel C Grant1,2

1Chemical and Biomedical Engineering, Florida State University, Tallahassee, FL, United States, 2National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, 3NeuroSpin, Paris, France, 4Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, United States

To date, there is a lack of characterization of metabolic markers in migraine studies. Though numerous studies implicate cerebral dysfunction, robust biomarkers are yet to be identified in the migraine brain. It thus follows that identification of specific metabolic changes, potentially influenced by excitatory and inhibitory neurotransmitters, may improve understanding of migraine onset and propagation while opening new avenues for therapy development.

With the goal of evaluating metabolic processes, diffusion-weighed spectroscopy is used to identify longitudinal changes in the in vivo thalamus of an acute rodent of migraine model.

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