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Abstract #2298

Diffusion tensor and Dixon imaging for guiding proton magnetic resonance spectroscopic evaluation of intra and extra myocellular lipids in skeletal muscle

Jiming Zhang1, Claudio Arena1, Afis Ajala2, Luning Wang3, Rajagopal Viswanatah Sekhar4, and Raja Muthupillai1

1Diagnostic and Interventional Radiology, CHI St Luke's Health, Houston, TX, United States, 2Physics, Univeristy of Houston, Houston, TX, United States, 3Philips Healthcare, Gainesville, FL, United States, 4Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX, United States

A different level of overlap between intramyocellular and extramyocellular lipids signal (EMCL and IMCL) depends on muscle fiber orientation and interstitial/fascial muscle fat tissue. We proposed diffusion tensor imaging and Dixon reconstructed fiber orientation map and maximum intensity projection fat maps to guide MR spectroscopy acquisition by carefully positioning the voxel so as to minimize these two effects. This method can be used to improve the consistency and accuracy of using MRS to quantify the intra skeletal muscle lipids and minimize variability in longitudinal studies such as evaluating disease progression or monitoring treatment progress

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