Abstract #2300

Investigating the effects of hypoxia on fibroblast invasion and metabolism

Jesus Pacheco-Torres¹, Tariq Shah¹, Flonne Wildes¹, Dimitry Artemov¹, and Zaver M. Bhujwalla^1,2,3

¹Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science. The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Fibroblast are considered as a major source of Collagen 1 fiber in the tumor stroma and to play a fundamental role in extracellular matrix (ECM) modification. Thus, cancer associated fibroblast has been related with increased tumor proliferation, invasion and metastasis. In the present study, we want to characterize the effect of different tumor microenvironments, as hypoxia and acidic extracellular pH, in the ability of prostate fibroblast cells to invade and degrade the extracellular matrix (ECM), as well with changes in their metabolome. We used our MR compatible cell perfusion system to assess this.

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