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Abstract #2324

Golden angle radial undersampling to accelerate synthetic CT generation with generative adversarial networks for prostate MR-guided Radiotherapy

Matteo Maspero1,2, Tom Bruijnen1,2, Mark H F Savenije1,2, Linda GW Kerkmeijer1, Peter R Seevinck2,3, and Cornelis A T van den Berg1,2

1Radiotherapy, UMC Utrecht, Utrecht, Netherlands, 2Center for Image Sciences, UMC Utrecht, Utrecht, Netherlands, 3Image Science Institute, UMC Utrecht, Utrecht, Netherlands

Synthetic-computed tomography (sCT) is crucial to enable MR-only radiotherapy and accurate MR-based dose calculations. In this work, we assessed the feasibility of using undersampled golden angle radial acquisition in combination with a conditional adversarial network to accelerate both acquisition and sCT generation for patients with prostate cancer. Golden angle radial acquisitions were simulated for several undersampling factors in a retrospective manner on 3D Cartesian spoiled gradient-echo data that were clinically acquired on fourty patients with prostate cancer. Dose planning demonstrated that accurate MR-based dose calculations were possible up to an undersampling factor 30 resulting in fast (<20s) sCT generation, which is of particular interest for online MR-guided radiotherapy.

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