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Abstract #2362

Serial ADC measurements in the T2 hyperintense, but otherwise normal-appearing white matter of glioblastoma patients correlates with survival

Aaron Rulseh1, Jan Sroubek2, Jan Klener2, and Josef Vymazal1

1Department of Radiology, Na Homolce Hospital, Prague, Czech Republic, 2Department of Neurosurgery, Na Homolce Hospital, Prague, Czech Republic

Glioblastoma is the most common malignant primary intracranial tumor and, despite multi-modal treatment, the prognosis remains poor. Additional tools to improve early detection or evaluate treatment response are highly desirable. We evaluated serial ADC measurements in the T2-hyperintense, but otherwise normal-appearing white matter at 1.5 T in thirty-five subjects diagnosed with glioblastoma and treated by surgical resection, radiotherapy, temozolomide and tumor-treating fields. We found that serially increasing ADC in the T2-hyperintense, but otherwise normal-appearing white matter in glioblastoma patients is prognostically favorable, with significantly greater overall survival and progression-free survival in patients with increasing ADC.

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