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Abstract #2379

Understanding the Biomechanical Signature of Pressurised Tumour on the Surrounding Tissue: a Modelling Study

Marco Fiorito1, Jack Lee1, Daniel Fovargue1, Adela Capilnasiu1, David Nordsletten1,2, and Ralph Sinkus1,3

1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, 3U1148, INSERM, Paris, France

Solid tumour growth is often associated with the accumulation of mechanical stresses acting on the surrounding host tissue. These forces alter the biomechanics of the adjacent soft tissue, generating a variation in stiffness resulting in a signature pattern that can be probed through MR-Elastography. The probed stiffness, however, is strongly dependent on the direction of propagation of the employed shear waves, leading to the reconstruction of anisotropic mechanical properties of the peri-tumoural tissue. Here we present, using theoretical and experimental means, a closed theoretical understanding of the observed alteration of tangent stiffness of soft tissue generated by pressurised tumour expansion.

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