Solid tumour growth is often associated with the accumulation of mechanical stresses acting on the surrounding host tissue. These forces alter the biomechanics of the adjacent soft tissue, generating a variation in stiffness resulting in a signature pattern that can be probed through MR-Elastography. The probed stiffness, however, is strongly dependent on the direction of propagation of the employed shear waves, leading to the reconstruction of anisotropic mechanical properties of the peri-tumoural tissue. Here we present, using theoretical and experimental means, a closed theoretical understanding of the observed alteration of tangent stiffness of soft tissue generated by pressurised tumour expansion.
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