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Abstract #2382

In vivo MR imaging of pelvic lymph nodes at ultra-high magnetic field (7T)

Tom Scheenen1,2, Bart Philips1, Rutger Stijns1, Ansje Fortuin1, Marloes Van Der Leest1, Mark Ladd3, Harald Quick2,4, Jelle Barentsz1, Stefan Rietsch2,4, Sacha Brunheim2,4, Stephan Orzada2, and Marnix Maas1

1Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, Netherlands, 2Erwin L Hahn Institute, Essen, Germany, 3German Cancer Research Center, Heidelberg, Germany, 4University Hospital Essen, Essen, Germany

The presence of metastases in pelvic lymph nodes marks the transition from local to systemic disease in many primary cancers in the lower abdomen. This crucial step in disease progression determines prognosis and the choice of treatment. Detection of metastatic lymph nodes is currently done with invasive diagnostic surgery, but could profit from USPIO-enhanced MRI. In this 7T study we present an in vivo anatomical baseline of number, size and location of visible lymph nodes in healthy volunteers, as well as the feasibility of using USPIO-enhanced MRI to detect suspicious lymph nodes in patients with prostate and rectal cancer.

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