Abstract #2391

Reductive microenvironment responsive gadolinium-based polymers as potential safe MRI contrast agents

Xueyang Xiao¹, Shiwei Guo², Kui Luo², and Qiyong Gong²

¹Huaxi MR Research Center (HMRRC), Department of Radiology, Sichuan University, Chengdu, Sichuan, China, ²Huaxi MR Research Center (HMRRC), Department of Radiology, Sichuan University, Chengdu,Sichuan, China

The abstract provided an alternative strategy to develop highly efficient and safe gadolinium-based MRI macromolecular contrast agents (Gd-mCAs) via conjugation of small molecular DOTA-Gd to a stimuli-responsive biodegradable and amphiphilic block DHPMA copolymer through a ROX-sensitive biocleavable disulfide bond. Also, its potential as efficient and safe MRI mCAs for cancer diagnosis have been investigated.

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