MRI phase images are increasingly used for Susceptibility Mapping or distortion correction. Spatial phase unwrapping is crucial but challenging: the computation time of PRELUDE, the current gold-standard method for robust, 3D unwrapping, increases rapidly with higher field strengths and longer echo times. A new method we have developed, SEGUE, produces similar results to PRELUDE in multi-echo brain and head-and-neck images, 1.6 to 83 times faster, but SEGUE has not been tested in pre-clinical high-field-strength phase images. Here, we show that SEGUE is similarly accurate and up to 4 times faster than PRELUDE in mouse brain images at 9.4 Tesla.
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