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Abstract #2469

Simultaneous Voxel-based Magnetic Susceptibility and Morphometry Analysis in Patients with Alzheimer’s Disease

Hirohito Kan1, Yuto Uchida2, Nobuyuki Arai1, Yoshino Ueki3, Yoshihiro Akagawa4, Harumasa Kasai1, Yasujiro Hirose1, Noriyuki Matsukawa2, and Yuta Shibamoto1

1Department of Radiology, Nagoya City University Hospital, Nagoya, Japan, 2Department of Neurology, Nagoya City University, Nagoya, Japan, 3Department of Rehabilitation Medicine, Nagoya City University, Nagoya, Japan, 4Department of Radiology, Toyokawa City Hospital, Yoyohashi, Japan

This abstract introduces an analysis pipeline of voxel-based magnetic susceptibility and morphometry (VBMSM) on single MR scan. To validate the proposed pipeline, we conducted VBMSM in control and Alzheimer’s disease (AD) groups. VBM was performed using the magnitude image. The susceptibility map was estimated by new dipole inversion utilized segmentation result. For whole brain susceptibility comparison, the susceptibility map was spatially normalized by the same transformation parameter for VBM. Significant susceptibility increases could be detected in regions associated withβ-amyloid deposition in AD. Brain atrophy also could be detected in AD. VBMSM is adaptable to neurodegenerative diseases including AD.

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