The quality of MRSI data depends strongly on B0 inhomogeneities, which cause broadening of metabolite resonances and decrease signal-to-noise ratios (SNR). B0 inhomogeneity is more severe at higher B0 field, diminishing the expected SNR and spectral resolution improvements. We have created simulation models which allow us to investigate how the spectral quality and quantification accuracy of MRSI changes with increasing spatial resolution and B0 field strength, using experimentally acquired data from 1.5T, 3T, 7T, and 9.4T. These simulations show not only that accurate MRSI quantification generally benefits from smaller voxels, but it does so particularly at UHF.
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