Abstract #2485

How does spatial resolution affect the spectral quality and quantification accuracy of whole-brain MRSI? A simulation study at 1.5T, 3T, 7T and 9.4T

Stanislav Motyka¹, Philipp Moser¹, Lukas Hingerl¹, Gilbert Hangel¹, Eva Heckova¹, Bernhard Strasser², Korbinian Eckstein¹, Simon Robinson¹, Benedikt A Poser³, Stephan Gruber¹, Siegfried Trattnig¹, and Wolfgang Bogner¹

¹Department of Biomedical Imaging and Image-guided Therapy, High Field MR Centre, Medical University of Vienna, Vienna, Austria, ²Department of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, ³Department of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands

The quality of MRSI data depends strongly on B0 inhomogeneities, which cause broadening of metabolite resonances and decrease signal-to-noise ratios (SNR). B0 inhomogeneity is more severe at higher B0 field, diminishing the expected SNR and spectral resolution improvements. We have created simulation models which allow us to investigate how the spectral quality and quantification accuracy of MRSI changes with increasing spatial resolution and B0 field strength, using experimentally acquired data from 1.5T, 3T, 7T, and 9.4T. These simulations show not only that accurate MRSI quantification generally benefits from smaller voxels, but it does so particularly at UHF.

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