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Abstract #2489

Comparison of ROI averaging and Spectral Localization by Imaging (SLIM) Using High Resolution 3D Echo Planar Spectroscopic Imaging (EPSI)

Sean Edmund Ellis1,2, Peter Adany1, Phil Lee1,2,3, and In-Young Choi1,2,3,4

1Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States, 2Department of Bioengineering, University of Kansas, Lawrence, KS, United States, 3Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, United States, 4Department of Neurology, University of Kansas Medical Center, Kansas City, KS, United States

Conventional spectroscopic imaging methods have limitations that make acquiring metabolic information for complexly-shaped brain regions a challenge. The following study compares two methods for acquiring the regional metabolic spectra for a complex compartment shape: spectral estimation via the spatial-averaging of voxels, and Spectral Localization by Imaging (SLIM). Both techniques used the original data sets acquired from 3D Echo Planar Spectroscopic Imaging sequences. The two methods were compared, with the results showing that SLIM could provide comparable compartment spectra using fewer voxel acquisitions without a significant drop in spectral quality.

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