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Abstract #2493

Spectroscopic imaging of macromolecule-suppressed J-difference editing of GABA at 3 Tesla

Kimberly Chan1,2,3 and Peter Barker2,3

1Department of Biomedical Engineering, The Johns Hopkins University School, Baltimore, MD, United States, 2Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

In this study, the feasibility of macromolecule-suppressed MR spectroscopic imaging (MRSI) of GABA in the human brain at 3T was investigated. PRESS-localized MRSI was performed for both macromolecule (MM)) suppressed GABA and non-suppressed (GABA+) editing. GABA concentrations and MM fractions were assessed and compared. Data quality metrics (B0 homogeneity, and GABA and water fit errors) were also calculated. A significant linear correlation of GABA+ with GABA concentrations was found. MM-suppressed GABA and GABA+ concentrations agreed with previously reported single-voxel values. Data quality metrics were also similar to those of prior single-voxel acquisitions.

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