Abstract #2509

Cardiac mechanical function and metabolism during hyperpolarized 13C experiments

Gregory P Barton¹, Erin B Macdonald¹, Kara N Goss^2,3, Marlowe W Eldridge^3,4, and Sean B Fain^1,4,5

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Medicine, University of Wisconsin-Madison, Madison, WI, United States, ³Pediatrics, University of Wisconsin-Madison, Madison, WI, United States, ⁴Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁵Radiology, University of Wisconsin-Madison, Madison, WI, United States

We investigated the relationship between contractile function and hyperpolarized (HP) [1-¹³C]pyruvate metabolism in a small animal model. We demonstrated significant functional changes in cardiac contractile function between pre- and post-infusion of [1-¹³C]pyruvate. The combined effect of infusion volume and pyruvate substrate likely explains most of the augmentation in myocardial mechanical function seen in these experiments. These data indicate the most appropriate time to image myocardial contractile function is soon as possible after HP ¹³C pyruvate infusion.

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