Abstract #2537

MR Spectroscopic Changes in Infants Exposed to Prenatal Opioids: A Pilot Study

Caroline Rae¹, Danielle Christmas², Ian Wright³, John Feller², Mohamed Abdel-Latif⁴, Sara Clews⁵, Janet Falconer², and Julee Oei²

¹Neuroscience Research Australia, Randwick, Australia, ²UNSW, Kensington, Australia, ³University of Wollongong, Wollongong, Australia, ⁴ANU, Canbera, Australia, ⁵ANU, Canberra, Australia

Proton spectra were obtained from the left caudate, left hippocampus and subventricular zone of the brains of one week old babies born to mothers who were opioid users. The study suggests that decreased brain volumes after prenatal opioid-exposure are associated with hippocampal spectral abnormalities with increased severity related to multiple opioid use.

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