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Abstract #2537

MR Spectroscopic Changes in Infants Exposed to Prenatal Opioids: A Pilot Study

Caroline Rae1, Danielle Christmas2, Ian Wright3, John Feller2, Mohamed Abdel-Latif4, Sara Clews5, Janet Falconer2, and Julee Oei2

1Neuroscience Research Australia, Randwick, Australia, 2UNSW, Kensington, Australia, 3University of Wollongong, Wollongong, Australia, 4ANU, Canbera, Australia, 5ANU, Canberra, Australia

Proton spectra were obtained from the left caudate, left hippocampus and subventricular zone of the brains of one week old babies born to mothers who were opioid users. The study suggests that decreased brain volumes after prenatal opioid-exposure are associated with hippocampal spectral abnormalities with increased severity related to multiple opioid use.

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