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Abstract #2540

Metabolic abnormalities in cingulate gyrus in HIV infection by 3D rosette spectroscopic imaging

Victor E. Yushmanov1, Jullie W. Pan1, Claudiu V. Schirda1, Hoby P. Hetherington1, Jeffry R. Alger2, Peter B. Barker3, Todd B. Parrish4, Ned Sacktor3, Michal Povazan3, and James T. Becker1

1University of Pittsburgh, Pittsburgh, PA, United States, 2University of California, Los Angeles, Los Angeles, CA, United States, 3Johns Hopkins University, Baltimore, MD, United States, 4Northwestern University, Chicago, IL, United States

The purpose of this study was to assess metabolic abnormalities in HIV infection by MRSI covering brain cortex and parts of striatum. Sixteen HIV-seropositive subjects (younger and older than 60) and age-matched 30 seronegative controls were evaluated using a fast rosette 3D MRSI sequence at 3T, segmentation and parcellation into 13 brain regions, and fGM regression statistics to evaluate abnormalities. MI/NAA, Cr/NAA, Ch/NAA and Ch/Cr increase in anterior and posterior cingulate as a function of HIV serostatus and age. Fast MRSI enables the detection of subtle metabolic abnormalities in HIV infection at clinically acceptable scan times (<10 min) at 3T.

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