Abstract #2540

Metabolic abnormalities in cingulate gyrus in HIV infection by 3D rosette spectroscopic imaging

Victor E. Yushmanov¹, Jullie W. Pan¹, Claudiu V. Schirda¹, Hoby P. Hetherington¹, Jeffry R. Alger², Peter B. Barker³, Todd B. Parrish⁴, Ned Sacktor³, Michal Povazan³, and James T. Becker¹

¹University of Pittsburgh, Pittsburgh, PA, United States, ²University of California, Los Angeles, Los Angeles, CA, United States, ³Johns Hopkins University, Baltimore, MD, United States, ⁴Northwestern University, Chicago, IL, United States

The purpose of this study was to assess metabolic abnormalities in HIV infection by MRSI covering brain cortex and parts of striatum. Sixteen HIV-seropositive subjects (younger and older than 60) and age-matched 30 seronegative controls were evaluated using a fast rosette 3D MRSI sequence at 3T, segmentation and parcellation into 13 brain regions, and fGM regression statistics to evaluate abnormalities. MI/NAA, Cr/NAA, Ch/NAA and Ch/Cr increase in anterior and posterior cingulate as a function of HIV serostatus and age. Fast MRSI enables the detection of subtle metabolic abnormalities in HIV infection at clinically acceptable scan times (<10 min) at 3T.

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