In this study, we explored the metabolic changes in WM and GM of patients with and without DNS using 1H MRS longitudinally at onset, 1, 3, and 9 months after CO intoxication. Decreased tNAA/Cr and increased Cho/Cr were observed in WM of patients with DNS as literatures have reported. The longitudinal change of Glx/Cr and Ins/Cr in WM and GM of patients with DNS implies themselves that may provide valuable information for monitoring DNS development.
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