A longitudinal study of astronauts with long duration exposure to microgravity showed intracranial volumetric expansion which did not return to baseline after a 1 year of post-flight recovery. These findings were associated with increased cerebral spinal fluid pulsatility through the cerebral aqueduct suggesting diminished intracranial compliance. Additionally, there was development of pituitary gland deformity similar to that seen in idiopathic intracranial hypertension implicating the presence of elevated intracranial pressure during spaceflight.
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