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Abstract #2556

MRI assessment of glymphatic function in the non-human primate brain

Ian Tagge1, Steven Kohama2, Theodore Hobbs3, Jeffrey Pollock4, Thierno Madjou Bah5, Jeffrey Iliff5, and William Rooney1

1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, 2Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, United States, 3Surgery, Oregon National Primate Research Center, Beaverton, OR, United States, 4Diagnostic Radiology, Oregon Health & Science University, Portland, OR, United States, 5Anesthesiology, Oregon Health & Science University, Portland, OR, United States

The astrocyte mediated exchange of cerebrospinal fluid and interstitial fluid comprise the glymphatic system, a physiology that facilitates waste removal in the brain parenchyma. Impaired solute and waste clearance may contribute to neurodegenerative conditions, and may also be associated with age. Here, we present preliminary measurements of glymphatic function in healthy adult and aged rhesus macaque brain via intrathecal injection and DCE-MRI. We demonstrate that kinetics of GBCA distribution in the CNS occur on timescales amenable to study using DCE-MRI techniques. Our preliminary results indicate that impairment in glymphatic physiology occurs with age in the rhesus macaque.

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