Abstract #2556

MRI assessment of glymphatic function in the non-human primate brain

Ian Tagge¹, Steven Kohama², Theodore Hobbs³, Jeffrey Pollock⁴, Thierno Madjou Bah⁵, Jeffrey Iliff⁵, and William Rooney¹

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, ²Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, United States, ³Surgery, Oregon National Primate Research Center, Beaverton, OR, United States, ⁴Diagnostic Radiology, Oregon Health & Science University, Portland, OR, United States, ⁵Anesthesiology, Oregon Health & Science University, Portland, OR, United States

The astrocyte mediated exchange of cerebrospinal fluid and interstitial fluid comprise the glymphatic system, a physiology that facilitates waste removal in the brain parenchyma. Impaired solute and waste clearance may contribute to neurodegenerative conditions, and may also be associated with age. Here, we present preliminary measurements of glymphatic function in healthy adult and aged rhesus macaque brain via intrathecal injection and DCE-MRI. We demonstrate that kinetics of GBCA distribution in the CNS occur on timescales amenable to study using DCE-MRI techniques. Our preliminary results indicate that impairment in glymphatic physiology occurs with age in the rhesus macaque.

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