Meeting Banner
Abstract #2564

Dynamic Contrast-Enhanced Imaging Reveals Region-Specific Blood-Brain Barrier Damage in Bipolar Depression

Lyn Kamintsky1, Kathleen A Cairns2, Ronel Veksler3, Chris Bowen1, Steven D Beyea1, Alon Friedman1, and Cynthia Calkin1

1Dalhousie University, Halifax, NS, Canada, 2Nova Scotia Health Authority, Halifax, NS, Canada, 3Ben-Gurion University, Beer Sheva, Israel

This study addresses the need for mechanism-based understanding and diagnosis of bipolar depression. Using dynamic contrast-enhanced MRI we identified extensive blood-brain barrier (BBB) leakage in 28% of bipolar patients (and zero controls). All bipolar patients with extensive BBB leakage also had insulin resistance and worse metabolic, psychiatric and cognitive symptoms. We found depression to be associated with region-specific BBB leakage, with the nucleus accumbens best predicting depression severity. Our findings highlight BBB damage as a mechanism contributing to the dysfunction of depression-associated brain regions, and suggest that insulin resistance increases the risk of extensive BBB leakage.

This abstract and the presentation materials are available to members only; a login is required.

Join Here