Abstract #2571

Quantitative Measurement of Glymphatic Flow in Man with Contrast-Enhanced MRI

Christopher G Filippi^1,2, Jared M Steinklein^1,2, Leah E Waldman^1,2, Xiangzhi Zhou^1,2, George Pinder³, and Richard Watts^4,5

¹Radiology, Lenox Hill Hospital, New York, NY, United States, ²Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, NY, United States, ³Department of Civil and Environmental Engineering, University of Vermont, Burlington, VT, United States, ⁴Department of Psychology, Yale University, New Haven, CT, United States, ⁵Department Radiology, University of Vermont, Burlington, VT, United States

Impairment in glial lymphatic "glymphatic" flow is hypothesized to be an etiologic factor in the development of Alzheimer’s disease (AD). We report a quantitative study of glymphatic flow in man, combining intrathecal administration of gadobutrol (macrocylic gadolinium-based contrast agent) with serial T₁-mapping to produce contrast concentration maps up to 3 days post-injection. This demonstrates proof-of-concept feasibility and offers data on the pharmacokinetics of glymhatic flow.

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