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Abstract #2573

Intra-Voxel Incoherent Motion imaging as a potential marker of parenchymal glymphatic flow

Swati Rane1, Elaine Peskind2,3, Rebecca Hendrickson2,3, Murray Raskind2,3, and Jalal B Andre1

1Radiology, University of Washington Medical Center, Seattle, WA, United States, 2Northwest Network Mental Illness Research, Education, and Clinical Center, VA Puget Sound, Seattle, WA, United States, 3Psychiatry and Behavioral Sciences, University of Washington Medical Center, Seattle, WA, United States

We tested the applicability of IVIM to detect increased glymphatic flow using the pseudo-diffusion coefficient (D*). Using known effects of prazosin, to increase interstitial fluid volume and glymphatic flow, we showed that D* increased significantly in 6 individuals before and 9-12 weeks after prazosin. This increase was greater than conventional diffusion. It was also larger than the inter-scan variability of D*, measured in 3 individuals 10 weeks apart.

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