Abstract #2573

Intra-Voxel Incoherent Motion imaging as a potential marker of parenchymal glymphatic flow

Swati Rane¹, Elaine Peskind^2,3, Rebecca Hendrickson^2,3, Murray Raskind^2,3, and Jalal B Andre¹

¹Radiology, University of Washington Medical Center, Seattle, WA, United States, ²Northwest Network Mental Illness Research, Education, and Clinical Center, VA Puget Sound, Seattle, WA, United States, ³Psychiatry and Behavioral Sciences, University of Washington Medical Center, Seattle, WA, United States

We tested the applicability of IVIM to detect increased glymphatic flow using the pseudo-diffusion coefficient (D*). Using known effects of prazosin, to increase interstitial fluid volume and glymphatic flow, we showed that D* increased significantly in 6 individuals before and 9-12 weeks after prazosin. This increase was greater than conventional diffusion. It was also larger than the inter-scan variability of D*, measured in 3 individuals 10 weeks apart.

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